Publications
Case Study Title
Share information on a previous project here to attract new clients. Provide a brief summary to help visitors understand the context and background of the work. Add details about why you created this project and what makes it significant.
Case Study Title
Share information on a previous project here to attract new clients. Provide a brief summary to help visitors understand the context and background of the work. Add details about why you created this project and what makes it significant.
Case Study Title
Share information on a previous project here to attract new clients. Provide a brief summary to help visitors understand the context and background of the work. Add details about why you created this project and what makes it significant.
Case Study Title
Share information on a previous project here to attract new clients. Provide a brief summary to help visitors understand the context and background of the work. Add details about why you created this project and what makes it significant.
Selected Research Publications
A comprehensive catalog of our lab's findings in molecular biology, viral pathogenesis, and oncogenic discovery.
Angewandte chemie • 2026
Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self-Sufficient Viral Restriction Factors
CYB5R3 is identified as a putative electron-transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune-silent, catalytically self-sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA), thereby enabling the development of novel antiviral strategies.
Journal of Biological inorganic chemistry • 2026
Emerging role of mitoNEET as mitochondrial sensor of hypoxia
In this perspective article, we discuss recent emerging evidence describing the mitoNEET [2Fe-2S] cluster role as a sensor of the cellular level of O2. These findings provide a mechanistic explanation of how mitochondria sense hypoxia, which affects their bioelectrochemistry and dynamics.
nanomedicine • 2026
Engineering next-generation therapeutics with antibody-mimetic ‘plug & play’ molecular assembly technology
This editorial discusses a new nanocage assembly technology we have developed for biomedical applications. We discuss the advantages of this technology and highlight the key questions that needs to be addressed to advance this technology.
Chemical communications • 2025
Controlling nanocage assembly, towards developing a one-health “plug & play” platform for targeted therapy
In this review, we will take a fresh look at the application of natural protein nanocages in nanomedicine by discussing our current understanding of their self-assembly process. We highlight our recent progress in engineering ferritin subunits to create a one-health “plug and play” platform technology to develop various therapeutic or prophylactic nanomedicines.
febs letters • 2025
The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel
The mitochondrial outer membrane iron–sulphur ([Fe-S]) protein mitoNEET is a target of the type-2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe-2S] cluster against NO oxidation and desensitization towards reduction by H2S. Our discovery suggests a molecular function of mitoNEET in sensing hypoxia by mitochondria.
Small • 2024
A Versatile Virus‐Mimetic Engineering Approach for Concurrent Protein Nanocage Surface‐Functionalization and Cargo Encapsulation
The HIV-1 Gag polypeptide precursors are mimicked to create precursors of nanocages (PRECs). It is shown that in the presence of a protease, the precursors are cleaved to form subunits that are spontaneously self-assembled to generate PINCs (Protein-induced nanocages). The PINC formation is used to encapsulate a cargo and concurrently decorate the nanocages’ surface with a protein.
current opinion in chemical biology • 2023
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism
We discuss how three [FeS] proteins involved in the innate immune response play a role in oncogene expression/function and oncometabolism. Our analysis highlights the importance of future research into understanding the [FeS] clusters' roles in cancer progression and proliferation. The outcomes of these studies will help identify new targets and develop new anticancer therapeutics.
Chemical communications • 2023
VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products
To discover new broad-spectrum antiviral nucleotide analogues from natural resources or through protein engineering, we have developed a sensitive in vivo selection assay named Viral polymerase-Inhibition Toxin-Associated Selection (VITAS). We show that the assay works with enzymes from three Kingdoms of life.