Laboratory of Bioinorganic Immunology & Drug Discovery
We are a dynamic and multinational team working in the Institute of Pharmaceutical Sciences at King's College London
Research
Our multidisciplinary research crosses the boundaries of bioinorganic chemistry and immunology/virology. We use a combination of molecular biology and cell biological methods, biophysical techniques, biochemical assays, and computational biochemistry.
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The research in our group is broadly divided into two themes: (i) Protein engineering to design and develop new therapeutics and (ii) Elucidating the function of iron-sulfur clusters, one of the oldest bioinorganic cofactors of life, at the crossroads of the immune response and cancer.
News & Events
Latest Publications
Latest Publications
The [2Fe-2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2-regulated nitric oxide access tunnel
Hypoxia (low oxygen level) sensing is a fundamental process contributing to many human diseases. We report a possible new mechanism via which hypoxia is sensed by mitochondria: O2 protection of iron-sulfur cluster protein mitoNEET. It is a new paradigm since iron-sulfur clusters are generally believed to be degraded by O2.
