Laboratory of Bioinorganic Immunology & Drug Discovery

We are a dynamic and multinational team working in the Institute of Pharmaceutical Sciences at King's College London

Research

Our multidisciplinary research crosses the boundaries of bioinorganic chemistry and immunology/virology. We use a combination of molecular biology and cell biological methods, biophysical techniques, biochemical assays, and computational biochemistry.

The research in our group is broadly divided into two themes: (i) Protein engineering to design and develop new therapeutics and (ii) Elucidating the function of iron-sulfur clusters, one of the oldest bioinorganic cofactors of life, at the crossroads of the immune response and cancer.

News & Events

A-ProX, a spinout based on the group discoveries and supported by King's Spinout Accelerator Program

MRC Gap Fund to Design and Develop Novel Multifunctional Antivirals.

M.Sc. Student Theo Situmorag Wins Best Thesis Prize

PhD student Thao Nghi Hoang's Review Article Published in Current Opinion in Chemical Biology

PhD Student Yujie Sheng Wins Best Poster Prize in COST Yong Investigator Meeting, TU Delft, the Netherlands

Latest Publications

The [2Fe-2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2-regulated nitric oxide access tunnel

Hypoxia (low oxygen level) sensing is a fundamental process contributing to many human diseases. We report a possible new mechanism via which hypoxia is sensed by mitochondria: O2 protection of iron-sulfur cluster protein mitoNEET. It is a new paradigm since iron-sulfur clusters are generally believed to be degraded by O2.